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中华心脏与心律电子杂志 ›› 2017, Vol. 05 ›› Issue (03) : 178 -182. doi: 10.3877/cma.j.issn.2095-6568.2017.03.015

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综述

缺血性心肌病心室肌细胞电重构的研究现状
李小龙1, 万征1,()   
  1. 1. 300070 天津,天津医科大学
  • 出版日期:2017-09-25
  • 通信作者: 万征
  • Published:2017-09-25
引用本文:

李小龙, 万征. 缺血性心肌病心室肌细胞电重构的研究现状[J]. 中华心脏与心律电子杂志, 2017, 05(03): 178-182.

慢性心力衰竭是一种复杂的临床症候群,为各种心脏病的终末阶段,正在成为21世纪最重要的心血管病症。而随着冠状动脉性心脏病(简称冠心病)发病率和心脏重构的增加,缺血性心肌病已逐渐成为心力衰竭的主要病因。心脏重构是心脏在病理环境中的一种适应性改变,包括心肌重构、血管重构、能量代谢重构和电重构。而其中电重构又是心律失常的基础,因此本文将分别从细胞层面和细胞外基质层面来阐述电重构。

图1 来自正常和衰竭心脏的心室肌细胞AP示意图
表1 心衰模型心室肌不同通道电流变化概况
图2 钙调蛋白与T管及肌浆网的关系模型图[30]
图3 心肌纤维化的病因及后果示意图
图4 组织纤维化对心肌细胞(红色细胞)束传导的预期效果的示意图
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