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中华心脏与心律电子杂志 ›› 2017, Vol. 05 ›› Issue (01) : 44 -46. doi: 10.3877/cma.j.issn.2095-6568.2017.05.013

所属专题: 文献

论著

波生坦预防大鼠颈动脉再狭窄与血清血管内皮生长因子相关性研究
张彦红1,(), 吴桂平1, 付鑫1, 李颖1, 曲晓婷1, 王涤非1   
  1. 1. 110002 沈阳医学院沈洲医院心血管内科
  • 出版日期:2017-03-25
  • 通信作者: 张彦红

Effect of Bosentan on Carotid Artery Restenosis in Rat and Correlation of Serum VEGF

Yanhong Zhang1,(), Guiping Wu1, Xin Fu1, Yin Li1, Xiaoting Qu1, Difei Wang1   

  1. 1. Department of Cardiology, Shenzhou Hospital of Shenyang Medical College, Shenyang 110002, China
  • Published:2017-03-25
  • Corresponding author: Yanhong Zhang
  • About author:
    Corresponding author: Zhang Yanhong, Email:
引用本文:

张彦红, 吴桂平, 付鑫, 李颖, 曲晓婷, 王涤非. 波生坦预防大鼠颈动脉再狭窄与血清血管内皮生长因子相关性研究[J/OL]. 中华心脏与心律电子杂志, 2017, 05(01): 44-46.

Yanhong Zhang, Guiping Wu, Xin Fu, Yin Li, Xiaoting Qu, Difei Wang. Effect of Bosentan on Carotid Artery Restenosis in Rat and Correlation of Serum VEGF[J/OL]. Chinese Journal of Heart and Heart Rhythm(Electronic Edition), 2017, 05(01): 44-46.

目的

探讨波生坦对大鼠颈动脉再狭窄的预防作用及与血清血管内皮生长因子(VEGF)水平的关系。

方法

36只Wistar大鼠随机分为假手术组,损伤组和波生坦组。损伤组及波生坦组模拟临床PTCA过程行左颈总动脉球囊损伤,波生坦组给予波生坦100 mg/(kg·d)灌胃(术前1 d直至处死)。在此基础上观测术后7 d、14 d时内膜面积管腔狭窄指数,并于术前及术后1周测定血清VEGF水平。

结果

波生坦组术后14 d血管内膜面积及管腔狭窄指数显著低于损伤组(P<0.001)。术后7 d损伤组、波生坦组血清VEGF水平较术前显著升高;波生坦组VEGF增幅高于损伤组,且术后7 d血清VEGF水平与管腔狭窄指数呈线性负相关。

结论

波生坦组可通过抑制血管内膜过度增生、升高血清VEGF水平预防再狭窄,有利于术后血管再内膜化。

Objective

To investigate the effect of Bosentan on carotid artery restenosis in rat and correlation of serum vascular endothelia growth factor (VEGF).

Methods

36 Wistar rats were divided randomly into 3 groups: control group , injured group and Bosentan group. Bosentan was administrated intragastricly to rats of Bosentan group.The balloon catheter injury was performed on left common carotid artery of rat by imitating the process of angioplasty. After 7 days, 14 days neointimal area(NIA) and stenosis index(SI) was calculated. Before and 7days after balloon injury, serum VEGF were detected.

Results

NIA and SI of Bosentan group were significantly decreased compared with injury group(P<0.001). Serum VEGF level significantly increased 7days after balloon injury both in injure group and Bosentan group. The increase rang in Bosentan group was higher than that in injury group(P<0.01). The serum VEGF level 7days after injury had linearly negatiuve correlation with SI.

Conclusion

Bosentan is effective on artery restenosis by inhibiting neointimal hyperplasis and increasing the serum VEGF level.

表1 术后7 d、14 d内膜面积比较(mm2±s)
表2 术后14 d内膜面积及管腔狭窄指数(SI)比较(±s)
表3 术前、术后7 d血清VEGF水平比较(pg/ml, ±s)
表4 术后7 d VEGF水平与14 d SI的关系(±s)
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