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中华心脏与心律电子杂志 ›› 2026, Vol. 14 ›› Issue (02) : 77 -81. doi: 10.3877/cma.j.issn.2095-6568.2026.02.003

年度报告

2025年室性心律失常诊疗进展:策略演进与技术创新
居维竹†(), 陈明龙   
  1. 210000 南京,南京医科大学第一附属医院(江苏省人民医院)心内科
  • 收稿日期:2026-02-26 出版日期:2026-06-25
  • 通信作者: 居维竹
  • 基金资助:
    江苏省卫计委重点课题(K2024058)

Advances in the diagnosis and treatment of ventricular arrhythmias: strategic evolution and technological innovation in 2025

Weizhu Ju†(), Minglong Chen   

  1. Department of Cardiology, The First Affiliated Hospital with Nanjing Medical University (Jiangsu Province Hospital), Nanjing 210029, China
  • Received:2026-02-26 Published:2026-06-25
  • Corresponding author: Weizhu Ju
引用本文:

居维竹, 陈明龙. 2025年室性心律失常诊疗进展:策略演进与技术创新[J/OL]. 中华心脏与心律电子杂志, 2026, 14(02): 77-81.

Weizhu Ju, Minglong Chen. Advances in the diagnosis and treatment of ventricular arrhythmias: strategic evolution and technological innovation in 2025[J/OL]. Chinese Journal of Heart and Heart Rhythm(Electronic Edition), 2026, 14(02): 77-81.

2025年,室性心律失常领域取得突破性进展,诊疗策略呈现三大转向:治疗策略前移、管理维度拓宽与技术持续革新。欧洲心律协会联合多学会发布首部《心外膜室性心律失常消融临床共识声明》,从解剖学特征、基质识别、穿刺路径及并发症防控等方面建立了标准化流程,推动技术规范化;欧洲心律协会联合美国心律协会首次发布《室性心动过速(室速)立体放疗的患者选择、靶区定义和数据转移》,这是业内首次对立体定向放疗治疗室速的全面技术总结性文件。三项标志性临床研究重塑实践范式:VANISH2试验证实,对于缺血性心肌病伴室速患者,导管消融作为一线治疗在降低复合终点事件方面优于抗心律失常药;POTCAST试验开创了代谢干预新维度,证明主动提升血钾水平至正常高值(4.5~5.0 mmol/L)可显著降低植入型心律转复除颤器患者室速事件与住院风险;VCAS试验验证了高压脉冲电场消融在器质性室速中的可行性,首次在人体中实现经心内膜单路径透壁消融,显著降低了室速负荷。上述进展从策略、理念到技术层面,共同构建了更立体、更主动的室性心律失常诊疗新体系,为临床决策提供了基于循证医学的清晰路径。

Significant progress has been made in the management of ventricular arrhythmias in 2025, characterized by three paradigm shifts: earlier therapeutic intervention, expanded management dimensions, and continuous technological innovation. The European Heart Rhythm Association, in collaboration with multiple societies, released the first international consensus statement on epicardial ventricular arrhythmia ablation, establishing standardized protocols encompassing anatomical considerations, substrate identification, access techniques, and complication prevention. The European Heart Rhythm Association, in collaboration with the Heart Rhythm Society, has released the first-ever consensus document on patient selection, target definition, and data transfer for stereotactic radiotherapy in ventricular tachycardia. This document represents the first comprehensive technical summary of stereotactic radiotherapy for the treatment of ventricular tachycardia in the field. Three landmark clinical trials have reshaped clinical practice, VANISH2 demonstrated that catheter ablation as first-line therapy was superior to antiarrhythmic drugs in reducing composite endpoints in ischemic cardiomyopathy patients with ventricular tachycardia. POTCAST pioneered a metabolic intervention approach by showing that actively maintaining serum potassium in the high-normal range (4.5-5.0 mmol/L) significantly reduced ventricular tachycardia events and hospitalizations in implantable cardioverter defibrillator recipients. VCAS validated the feasibility of high-voltage pulsed field ablation for structural ventricular tachycardia, achieving transmural lesions via endocardial-only approach in humans and dramatically reducing arrhythmia burden. Collectively, these advances, spanning from treatment strategies and clinical concepts, to ablation technologies, are shaping a more comprehensive and proactive paradigm for ventricular arrhythmia management, offering evidence-based guidance for clinical decision-making.

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中华医学会心电生理和起搏分会, 中国医师协会心律学专业委员会. 2020室性心律失常中国专家共识解读[J]. 中华心律失常学杂志, 2020, 24(4): 348-350.
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翟正芹, 周益锋. 脉冲电场消融治疗室性心律失常进展[J/OL]. 中华心脏与心律电子杂志, 2025, 13(4): 229-234.
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Sapp JL, Tang A, Parkash R, et al. Catheter ablation or antiarrhythmic drugs for ventricular tachycardia[J]. N Engl J Med, 2025, 392(8): 737-747.
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Jøns C, Zheng C, Winsløw U, et al. Increasing the potassium level in patients at high risk for ventricular arrhythmias[J]. N Engl J Med, 2025, 393(20): 1979-1989.
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Reddy VY, Koruth JS, Peichl P, et al. High-voltage focal pulsed field ablation to treat scar-related ventricular tachycardia: the first-in-human VCAS trial[J]. Circulation, 2025, 152(24): 1691-1704.
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Arya A, Di Biase L, Bazán V, et al. Epicardial ventricular arrhythmia ablation: a clinical consensus statement of the European Heart Rhythm Association of the European Society of Cardiology and the Heart Rhythm Society, the Asian Pacific Heart Rhythm Society, the Latin American Heart Rhythm Society, and the Canadian Heart Rhythm Society[J]. Europace, 2025, 28, 27(4):euaf055.
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Zeppenfeld K, Rademaker R, Al-Ahmad A, et al. Patient selection, ventricular tachycardia substrate delineation, and data transfer for stereotactic arrhythmia radioablation: a clinical consensus statement of the European Heart Rhythm Association of the European Society of Cardiology and the Heart Rhythm Society[J]. Europace, 2025, 27(4):euae214.
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