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中华心脏与心律电子杂志 ›› 2026, Vol. 14 ›› Issue (02) : 105 -111. doi: 10.3877/cma.j.issn.2095-6568.2026.02.007

综述

冠状动脉微循环的神经调节研究进展
吴晓光, 赵晓辉, 闫小响, 马根山, 陆远, 韩渊, 谷阳, 董勇, 李鹏, 王连生, 李春坚, 孔祥清, 李勇†()   
  1. 1210029 南京,南京医科大学第一附属医院(江苏省人民医院)心血管内科
    2400037 重庆,陆军军医大学第二附属医院(新桥医院)心血管内科
    3200025 上海,上海交通大学医学院附属瑞金医院心血管内科
    4210000 南京,东南大学附属中大医院心血管内科
    5221000 徐州,徐州医科大学附属医院心血管内科
    6510515 广州,南方医科大学南方医院心血管内科
    7223001 淮安,南京医科大学附属淮安市第一人民医院心血管内科
    8450000 郑州,郑州市第七人民医院心血管内科
  • 收稿日期:2026-06-03 出版日期:2026-06-25
  • 通信作者: 李勇
  • 基金资助:
    南京市科技发展计划(2025SX00001279-202501279)

Research advances in neural regulation of coronary microcirculation

Xiaoguang Wu, Xiaohui Zhao, Xiaoxiang Yan, Genshan Ma, Yuan Lu, Yuan Han, Yang Gu, Yong Dong, Peng Li, Liansheng Wan, Chunjian Li, Xiangqing Kong, Yong Li†()   

  1. 1Department of Cardiology, The First Affiliated Hospital with Nanjing Medical University(Jiangsu Province Hospital), Nanjing 210029, China
    2Department of Cardiology, The Second Affiliated Hospital of Army Medical University (Xinqiao Hospital), Chongqing 400037, China
    3Department of Cardiology, Ruijin Hospital Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
    4Department of Cardiology, Zhongda Hospital Southeast University, Nanjing 210000, China
    5Department of Cardiology, Xuzhou Medical University Affiliated Hospital, Xuzhou 221000, China
    6Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
    7Department of Cardiology, Nanjing Medical University Affiliated Huai'an First People's Hospital, Huai'an 223001, China
    8Department of Cardiology, Zhengzhou Seventh People's Hospital, Zhengzhou 450000, China
  • Received:2026-06-03 Published:2026-06-25
  • Corresponding author: Yong Li
引用本文:

吴晓光, 赵晓辉, 闫小响, 马根山, 陆远, 韩渊, 谷阳, 董勇, 李鹏, 王连生, 李春坚, 孔祥清, 李勇. 冠状动脉微循环的神经调节研究进展[J/OL]. 中华心脏与心律电子杂志, 2026, 14(02): 105-111.

Xiaoguang Wu, Xiaohui Zhao, Xiaoxiang Yan, Genshan Ma, Yuan Lu, Yuan Han, Yang Gu, Yong Dong, Peng Li, Liansheng Wan, Chunjian Li, Xiangqing Kong, Yong Li. Research advances in neural regulation of coronary microcirculation[J/OL]. Chinese Journal of Heart and Heart Rhythm(Electronic Edition), 2026, 14(02): 105-111.

冠状动脉微循环的神经调节异常是导致心肌缺血症状但冠状动脉造影未见阻塞性病变的重要机制之一。研究表明,交感神经与副交感神经通过α/β肾上腺素能受体、胆碱能受体及多种神经递质(如神经肽Y、降钙素基因相关肽等)动态调控微血管张力,其功能紊乱与非阻塞性冠状动脉缺血密切相关。本文基于冠状动脉微循环神经支配的解剖与功能特征,系统综述其调控机制,为临床诊断和治疗策略的优化提供理论依据。

Abnormal neuroregulation of coronary microcirculation is one of the important mechanisms leading to myocardial ischemia symptoms, but coronary angiography shows no obstructive lesions. Studies have shown that sympathetic and parasympathetic nerves dynamically regulate microvascular tension through α/β adrenergic receptors, cholinergic receptors and various neurotransmitters (such as neuropeptide Y and calcitonin gene-related peptide). And their dysfunction is closely related to non-obstructive coronary artery ischemia. Based on the anatomical and functional characteristics of coronary microcirculation innervation, this paper systematically summarizes its regulation mechanism, which provides theoretical basis for clinical diagnosis and optimization of treatment strategy.

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