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中华心脏与心律电子杂志 ›› 2022, Vol. 10 ›› Issue (01) : 27 -31. doi: 10.3877/cma.j.issn.2095-6568.2022.01.007

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脉冲电场消融治疗心房颤动
唐闽1,()   
  1. 1. 100037 北京,中国医学科学院 北京协和医学院 国家心血管病中心 心血管疾病国家重点实验室 阜外医院心律失常中心
  • 收稿日期:2022-02-09 出版日期:2022-03-25
  • 通信作者: 唐闽
  • 基金资助:
    国家自然科学基金资助项目(U1913210)

Pulsed field ablation for treatment of atrial fibrillation

Min Tang1,()   

  1. 1. Center of Arrhythmia, Fuwai Hospital,State Key Laboratory of Cardiovascular Disease,National Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100037, China
  • Received:2022-02-09 Published:2022-03-25
  • Corresponding author: Min Tang
引用本文:

唐闽. 脉冲电场消融治疗心房颤动[J]. 中华心脏与心律电子杂志, 2022, 10(01): 27-31.

Min Tang. Pulsed field ablation for treatment of atrial fibrillation[J]. Chinese Journal of Heart and Heart Rhythm(Electronic Edition), 2022, 10(01): 27-31.

脉冲电场消融(pulsed field ablation,PFA)是直流电消融的“变种”。PFA可实现间歇性、短时程和不同强度的脉冲场释放,从而造成特定细胞的可逆和不可逆“电穿孔”损伤。基于优越的组织细胞特异性,PFA在过去的数十年间分别在基因转染、制药工程、食品加工和实体肿瘤的临床治疗中大放异彩。本文立足于PFA的发展历史、损伤机制、不良反应、动物试验和人体试验,以系统地介绍PFA治疗心房颤动的原理和应用现状。

图1 脉冲电场隔离肺静脉示例[1A:左下肺静脉口部消融前(左)可见34、45和56电极标测到肺静脉电位(箭头);消融后(右)相应肺静脉电位消失;1B:右前斜体位透视见导管以花瓣状展开消融左下肺静脉口部;1C:心腔内超声见导管以梭状展开紧密贴靠于左下肺静脉口部]
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