探讨胺碘酮联合厄贝沙坦治疗心力衰竭合并心律失常的临床疗效及机制。

选取本院2015年8月至2016年8月收治的心律失常合并慢性心力衰竭患者124例作为研究对象，根据随机数字表法分为研究组和对照组，每组62例。对照组给予常规心血管药物和胺碘酮治疗，研究组在对照组基础上联合厄贝沙坦治疗。记录患者治疗前后每搏心输出量(SV)、左心室收缩末期内径(LVESD)、左心室舒张末期内径(LVEDD)、左室射血分数(LVEF)，以及患者服药后心脏以及机体不良反应发生率。

研究组心功能、心律失常治疗的总有效分别是91.94%、95.16%，优于对照组(82.26%、80.65%)，比较显示存在统计学差异(P<0.05)；治疗后研究组和对照组SV、LVEF、LVESD、LVEDD指数均优于治疗前，且研究组优于参照组，比较显示存在统计学差异(P<0.05)；研究组治疗后心脏不良反应和机体不良反应发生率分别为3.23%、3.23%优于参照组(12.90%、12.90%)，比较显示存在统计学差异(P<0.05)。

胺碘酮联合厄贝沙坦治疗心力衰竭合并心律失常临床疗效显著，可有效改善患者心脏功能，降低服药后不良反应发生和对心脏的副作用。

To investigate the clinical efficacy and mechanism of amiodarone combined with irbesartan in the treatment of heart failure complicated with arrhythmia..

and the clinical efficacy of amiodarone plus irbesartanpatients for heart failure complicated with arrhythmia, taking the sample of 124 patients with arrhythmia complicated with chronic heart failure who enrolled in the hospital from August 30, 2015 to August 30, 2016. They were randomly divided into control groupand study group, each 62. The former was given conventional cardiovascular and amiodarone treatment, with which irbesartan was treated to the latter. Before and after treatment, the cardiac output per stroke, the left ventricular end-diastolic diameter and the rate of adverse heart or body reaction to treatment and subsequent in-hospital were observed and recorded.

With a significant difference (P<0.05), the result showed that the total cardiac function and arrhythmia of the study group were respectively 91.94% and 95.16%, better than the control group (82.26%, 80.65%). The SV, LVEF, LVESD and LVEDD were superior to those before treatment, and the study group perform better than the control group(P<0.05). The rate of adverse reaction of heart and body (3.23%, 3.23%) in the study group was significantly lower than those in the control group (12.90%, 12.90%), (P<0.05).

Amiodarone combined with irbesartan in the treatment of heart failure with arrhythmia clinical efficacy, can effectively improve the patient′s heart function, reduce adverse reactions after taking drugs and the side effects of the heart.