Relationship Between Postprandial Hypotension and Mild Cognitive Impairment in elderly patients

doi:10.3877/cma.j.issn.2095-6568.2017.03.011

Abstract

Abstract:

Objectives

To explore the relationship between postprandial hypotension (PPH) and mild cognitive impariment(MCI) in elderly patients.

Methods

296 senile inpatients with mean age of 78.95 years (range from 60 to 95 years) were recruited. 194 patients were male (65.5%). Their postprandial blood pressures were measured every 30 minutes, and then divided into 2 groups according to the definition of PPH: PPH group and non-PPH group. Cognitive function was assessed by Peking Union Medical College Hospital vision of Montreal Cognitive Assessment (MoCA-P), then divided into 2 groups according to the definition of MCI: MCI group and normal cognition (NC) group.

Results

There are 146 patients met PPH criteria (49.3%). 125 patients had MCI (42.2%). Compared with the non-PPH group, the PPH group had lower MoCA score (24.76±3.96 vs 25.66±2.98, P=0.028). The incidence of MCI in PPH group was significantly higer than in non-PPH group (50.7% vs 34%, P=0.005). Logistic regression analysis showed that age, average education years and PPH independently correlated with MCI [OR(95%CI) was 1.06(1.02-1.11), 0.83(0.76-0.90), 1.98(1.16-3.36) respectively, all P<0.05].

Conclusion

PPH may be an independent risk factor for MCI in elderly patients.

Key words: Postprandial hypotension, Mild cognitive impariment, Ambulatory blood pressure

Juan Jiang, Yanan Wei, Lihua Deng, Yuanyuan Chen, Hui Bao, Jie Liu, Jingtong Wang. Relationship Between Postprandial Hypotension and Mild Cognitive Impairment in elderly patients[J]. Chinese Journal of Heart and Heart Rhythm(Electronic Edition), 2017, 05(03): 166-168.

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References 12

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项目	PPH组(146例)	非PPH组(150例)	P值
男/女(例数)	94/52	100/50	0.386
年龄(岁)	81.30±6.88	76.66±8.71	<0.001
BMI(kg/m²)	24.13±3.34	23.86±3.38	0.484
eGFR[ml/(min·1.73 m²)]	66.51±18.96	74.562±17.10	<0.001
24 h平均收缩压(mmHg)	126.51±13.77	121.45±13.30	0.001
24 h平均舒张压(mmHg)	67.40±7.19	67.37±7.49	0.978
24 h平均脉压(mmHg)	59.12±11.95	54.07±11.65	<0.001
高血压[例(%)]	112(76.7)	102(68)	0.061
冠心病[例(%)]	62(42.5)	59(39.3)	0.334
糖尿病[例(%)]	69(47.3)	85(56.7)	0.130
降压药物[例(%)]	114(78.1)	105(70)	0.145
钙拮抗剂[例(%)]	62(42.5)	59(39.3)	0.637
β受体阻滞剂[例(%)]	51(34.9)	46(30.7)	0.459
ACEI[例(%)]	2(1.4)	8(5.3)	0.104
ARB[例(%)]	64(43.8)	51(34)	0.095
利尿剂[例(%)]	19(13.1)	18(12)	0.861

项目	PPH组(146例)	非PPH组(150例)	P值
男/女(例数)	94/52	100/50	0.386
年龄(岁)	81.30±6.88	76.66±8.71	<0.001
BMI(kg/m²)	24.13±3.34	23.86±3.38	0.484
eGFR[ml/(min·1.73 m²)]	66.51±18.96	74.562±17.10	<0.001
24 h平均收缩压(mmHg)	126.51±13.77	121.45±13.30	0.001
24 h平均舒张压(mmHg)	67.40±7.19	67.37±7.49	0.978
24 h平均脉压(mmHg)	59.12±11.95	54.07±11.65	<0.001
高血压[例(%)]	112(76.7)	102(68)	0.061
冠心病[例(%)]	62(42.5)	59(39.3)	0.334
糖尿病[例(%)]	69(47.3)	85(56.7)	0.130
降压药物[例(%)]	114(78.1)	105(70)	0.145
钙拮抗剂[例(%)]	62(42.5)	59(39.3)	0.637
β受体阻滞剂[例(%)]	51(34.9)	46(30.7)	0.459
ACEI[例(%)]	2(1.4)	8(5.3)	0.104
ARB[例(%)]	64(43.8)	51(34)	0.095
利尿剂[例(%)]	19(13.1)	18(12)	0.861

项目	PPH组(146例)	非PPH组(150例)	P值
MoCA评分(分)	24.76±3.96	25.66±2.98	0.028
MCI[例(%)]	74(50.7)	51(34%)	0.005
受教育年限(年)	14.15±3.28	13.75±3.59	0.321

项目	PPH组(146例)	非PPH组(150例)	P值
MoCA评分(分)	24.76±3.96	25.66±2.98	0.028
MCI[例(%)]	74(50.7)	51(34%)	0.005
受教育年限(年)	14.15±3.28	13.75±3.59	0.321

变量	B值	SE	χ²值	OR值	95%CI	P值
年龄	0.063	0.021	8.599	1.065	1.021～1.110	0.003
受教育年限	－0.189	0.042	19.859	0.828	0.762～0.900	<0.001
PPH	0.681	0.271	6.317	1.975	1.162～3.359	0.012

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