To evaluate the effect of the treatment of children with arrhythmia in the treatment of middle and small dose amiodarone, and to analyze the changes of thyroid hormone levels in children with drug use.

The 116 children with arrhythmia treated in the Chinese Hospital of Linyi County from August 2016 to August 2017 were selected as study subjects. According to the random number table method, they were randomly divided into a control group and an observation group, 58 cases in each group. Select propafenone hydrochloride tablets and small doses of amiodarone hydrochloride to treat the effects of abnormal heart rhythm in the two groups of patients.Compare the changes of thyroid hormone levels and adverse drug reactions before and after treatment.

The effect of arrhythmia treatment was observed, the effective rate of treatment in the observation group(96.55%)was compared with the control group(86.21%), and the difference was statistically significant(P<0.05). There was no significant difference in thyroid hormone levels between the two groups before and after treatment(P>0.05). The incidence of adverse drug reactions(ADR)in the observation group(5.17%)was significantly higher than that in the control group(17.24%), and the difference was statistically significant.

In the treatment of children with arrhythmia, small dose of amiodarone has positive effect on improving the symptoms of arrhythmia, the incidence of adverse reaction is low, and there is no obvious effect on the level of thyroid hormone in children.It should be popularized and applied in clinical practice.