Risk Factors and Influence of Frailty in Elderly Patients with Chronic Heart Failure

doi:10.3877/cma.j.issn.2095-6568.2017.04.012

Abstract

Abstract:

Objective

The aim of this study was to analysis the prevalence, risk factor of frailty in elderly patients with chronic heart failure.

Methods

The elderly patients with chronic heart failure in General Hospital of Guangzhou Military Command of PLA from 2013 to 2017 were enrolled in the study.The demographic characteristics and medical record data were collected.All patients received frailty assessment with Fried criteria.A total of 371 patients aged 65-96(80.5±6.0)years were included in this study.

Result

The prevalence rate of frailty was 21.3%, with 16.4% and 26.4% in patients of 65-79 and ≥ 80 years respectively(P<0.05). The prevalence of frailty in elderly patients with chronic heart failure with renal insufficiency and cerebrovascular disease was significantly higher in with the two diseases than without (P<0.05). The prevalence of frailty increased with the number of major complications in elderly patients with chronic heart failure.Multivariate Logistic regression analysis indicated that elderly, renal insufficiency, cerebrovascular disease and NYHA classification were significantly associated with frailty (P<0.05).

Conclusion

The prevalence rate of frailty in patients was increased with age and the number of major complications.The elderly, renal insufficiency, cerebrovascular disease and NYHA classification may be the independent risk factors for frailty in elderly patients with chronic heart failure.

Key words: Elderly, Chronic heart failure, Frailty, Complication

Xinxue Quan, Zhiquan Xie. Risk Factors and Influence of Frailty in Elderly Patients with Chronic Heart Failure[J]. Chinese Journal of Heart and Heart Rhythm(Electronic Edition), 2017, 05(04): 229-232.

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References 6

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变量		非衰弱(n＝292)	衰弱(n＝79)	t(χ²)值	P值
男性[例(%)]		251(86.0)	69(87.3)	0.10^a	0.751
年龄(岁)		80.0±6.0	82.3±5.6	－3.05	0.002
BMI(kg/m²)		24.0±3.1	23.9±3.4	0.23	0.815
合并症数量		3.5±1.3	4.0±1.3	－3.02	0.003
LVEF<40%		192(65.8)	53(67.1)	0.05^a	0.824
NYHA分级[例(%)]		?	?	?	?
?	Ⅱ级	205(70.2)	30(38.0)	27.82^a	0.000
?	Ⅲ级	87(29.8)	46(58.2)	21.86^a	0.000
?	Ⅳ级	0	3(3.8)	－	－

变量		非衰弱(n＝292)	衰弱(n＝79)	t(χ²)值	P值
男性[例(%)]		251(86.0)	69(87.3)	0.10^a	0.751
年龄(岁)		80.0±6.0	82.3±5.6	－3.05	0.002
BMI(kg/m²)		24.0±3.1	23.9±3.4	0.23	0.815
合并症数量		3.5±1.3	4.0±1.3	－3.02	0.003
LVEF<40%		192(65.8)	53(67.1)	0.05^a	0.824
NYHA分级[例(%)]		?	?	?	?
?	Ⅱ级	205(70.2)	30(38.0)	27.82^a	0.000
?	Ⅲ级	87(29.8)	46(58.2)	21.86^a	0.000
?	Ⅳ级	0	3(3.8)	－	－

合并症	是否合并(例)	非衰弱[例(%)]	衰弱[例(%)]	χ²值	P值
缺血性心肌病史	是(276)	215(77.9)	61(22.1)	0.42	0.517
?	否(95)	77(81.1)	18(18.9)	?	?
高血压	是(329)	258(78.4)	71(21.6)	0.14	0.706
?	否(42)	34(81.0)	8(19.0)	?	?
糖尿病	是(138)	108(78.3)	30(21.7)	0.03	0.872
?	否(233)	184(79.0)	49(21.0)	?	?
脑血管病	是(183)	134(73.2)	49(26.8)	6.48	0.011
?	否(188)	158(84.0)	30(16.0)	?	?
高脂血症	是(189)	146(77.2)	43(22.8)	0.49	0.485
?	否(182)	146(80.2)	36(19.8)	?	?
房颤	是(94)	72(76.6)	22(23.4)	0.34	0.563
?	否(277)	220(79.4)	57(20.6)	?	?
肾功能不全	是(112)	78(69.6)	34(30.4)	7.86	0.005
?	否(259)	214(82.6)	45(17.4)	?	?
0～1种	是(21)	19(90.5)	2(9.5)	10.47^a	0.001^a
2～4种	是(253)	208(82.2)	45(17.8)	18.63^a	0.000^a
5～7种	是(97)	65(67.0)	32(33.0)	?	?

合并症	是否合并(例)	非衰弱[例(%)]	衰弱[例(%)]	χ²值	P值
缺血性心肌病史	是(276)	215(77.9)	61(22.1)	0.42	0.517
?	否(95)	77(81.1)	18(18.9)	?	?
高血压	是(329)	258(78.4)	71(21.6)	0.14	0.706
?	否(42)	34(81.0)	8(19.0)	?	?
糖尿病	是(138)	108(78.3)	30(21.7)	0.03	0.872
?	否(233)	184(79.0)	49(21.0)	?	?
脑血管病	是(183)	134(73.2)	49(26.8)	6.48	0.011
?	否(188)	158(84.0)	30(16.0)	?	?
高脂血症	是(189)	146(77.2)	43(22.8)	0.49	0.485
?	否(182)	146(80.2)	36(19.8)	?	?
房颤	是(94)	72(76.6)	22(23.4)	0.34	0.563
?	否(277)	220(79.4)	57(20.6)	?	?
肾功能不全	是(112)	78(69.6)	34(30.4)	7.86	0.005
?	否(259)	214(82.6)	45(17.4)	?	?
0～1种	是(21)	19(90.5)	2(9.5)	10.47^a	0.001^a
2～4种	是(253)	208(82.2)	45(17.8)	18.63^a	0.000^a
5～7种	是(97)	65(67.0)	32(33.0)	?	?

自变量	回归系数	标准误	Wald χ²值	P值	OR(95%CI)
年龄	0.26	0.12	5.08	0.02	1.30(1.03，1.62)
肾功能不全	0.66	0.31	4.39	0.03	1.93(1.04，3.56)
脑血管病史	0.66	0.32	4.22	0.04	1.93(1.03，3.62)
合并症数量	0.05	0.16	0.10	0.75	1.05(0.77，1.43)
NYHA分级	1.40	0.27	27.66	<0.01	4.04(2.40，6.81)

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