Curative effect of sofren injection on unstable angina pectoris and its influence on platelet function

doi:10.3877/cma.j.issn.2095-6568.2018.02.001

Abstract

Abstract:

Objective

To study the curative effect of sofren injection on unstable angina pectoris and its influence on platelet function.

Methods

A total of 76 patients with unstable angina pectoris admitted to Henan Provincial People's Hospital from July of 2016 to December of 2017 were randomly divided into control group and observation group, 38 cases in each group. The control group received routine drug treatment, while the observation group received sofren injection on the basis of routine drug treatment. The curative effect, plasma plasminogen activator inhibitor 1 (PAI-1), thromboxane B2 (TXB2), platelet aggregation rate before and after treatment were compared between the two groups.

Results

The total effective rate was 71.05% (27/38) in the control group and 92.11% (35/38) in the observation group, and the difference was statistically significant (P<0.05). After treatment for 4 weeks, the levels of PAI-1, TXB2 and platelet aggregation rate in the observation group were lower than those in the control group (P<0.05).

Conclusion

Sofren injection can effectively alleviate the symptoms of patients with unstable angina pectoris and improve platelet function, which is worthy of clinical promotion.

Key words: Unstable angina pectoris, Sofren injection, Curative effect, Platelet function

Jianli Li, Jiangtao Cheng. Curative effect of sofren injection on unstable angina pectoris and its influence on platelet function[J]. Chinese Journal of Heart and Heart Rhythm(Electronic Edition), 2018, 06(02): 65-67.

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URL: https://zhxzyxldzzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2095-6568.2018.02.001

https://zhxzyxldzzz.cma-cmc.com.cn/EN/Y2018/V06/I02/65

组别	例数	PAI－1(μg/L)		TXB2(ng/L)		血小板聚集率(%)
组别	例数	治疗前	治疗4周后	治疗前	治疗4周后	治疗前	治疗4周后
对照组	38	44.27±4.60	12.96±2.02^a	174.03±52.38	70.49±16.18^a	74.15±3.82	37.97±1.76^a
观察组	38	44.50±4.23	7.72±1.85^ab	174.21±50.13	53.16±15.22^ab	74.40±3.55	32.01±1.17^ab

组别	例数	PAI－1(μg/L)		TXB2(ng/L)		血小板聚集率(%)
组别	例数	治疗前	治疗4周后	治疗前	治疗4周后	治疗前	治疗4周后
对照组	38	44.27±4.60	12.96±2.02^a	174.03±52.38	70.49±16.18^a	74.15±3.82	37.97±1.76^a
观察组	38	44.50±4.23	7.72±1.85^ab	174.21±50.13	53.16±15.22^ab	74.40±3.55	32.01±1.17^ab

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