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Chinese Journal of Heart and Heart Rhythm(Electronic Edition) ›› 2026, Vol. 14 ›› Issue (01): 28-35. doi: 10.3877/cma.j.issn.2095-6568.2026.01.005

• Clinical Research • Previous Articles    

A cohort study on the association between blood lipid indicators and the incidence of cardiovascular disease among rural residents in Xinjiang Corps

Zeyu Du1, Heng Guo1, Xianghui Zhang1, Jia He1, Kelamu Mulatibieke1, Rulin Ma1, Shuxia Guo1,2,()   

  1. 1Department of Preventive Medicine, College of Medicine, Shihezi University, Shihezi 832000, China
    2Key Laboratory of High-Incidence Diseases Prevention and Control in Central Asia, National Health Commission of the People's Republic of China, Shihezi 832000, China
  • Received:2025-12-16 Online:2026-03-25 Published:2026-04-24
  • Contact: Shuxia Guo

Abstract:

Objective

To quantify the strength of association between multiple lipid parameters and incident cardiovascular disease (CVD) and to evaluate their predictive value, so as to provide evidence for CVD prevention strategies and risk prediction in rural Xinjiang.

Methods

This was a cohort study. In Septemper 2016, residents of the 51st Regiment, Tumshuq, 3rd Division, Xinjiang Corps (the most representative rural settlement of the Uyghur people within the Xinjiang Corps) were enrolled as the baseline population. Information on sociodemographics (age, sex, et al), lifestyle (physical activity, smoking, alcohol use et al), anthropometry (height, weight, blood pressure et al), and laboratory indices—total cholesterol (TC), triglycerides (TG), high-density-lipoprotein cholesterol (HDL-C) and low-density-lipoprotein cholesterol (LDL-C), were collected. Uyghur participants were followed up from Septemper 2019 to December 2023. Cumulative incidence was estimated with Kaplan-Meier curves. Cox proportional-hazards models were used to estimate associations between each lipid marker and incident CVD. Discrimination was assessed with receiver-operating-characteristic (ROC) curves.

Results

A total of 9 183 residents [mean age (38.1±14.1) years, 50.5% (4 638/9 183) male] were included. During a median follow-up of 6.3 (5.6–6.9) years, 1 079 new CVD events occurred, giving a cumulative incidence of 11.7% (1 079/9 183). After multivariable adjustment, remnant cholesterol, non-HDL-C, cardiovascular risk index-Ⅰ(TC/HDL-C), CVD risk index-Ⅱ (LDL-C/HDL-C)and TG/HDL-C ratio were associated with incident CVD. cardiovascular risk index-Ⅰ showed the strongest relationship: hazard ratios (HR) across quartiles were 1.87 (95%CI 1.51–2.31), 2.20 (95%CI 1.79–2.72) and 2.40 (95%CI 1.96–2.95). Corresponding HRs for cardiovascular risk index-Ⅱ were 1.75 (95%CI 1.43–2.15), 2.14 (95%CI 1.76–2.62) and 2.22 (95%CI 1.82–2.71). All lipid measures improved model discrimination, CVD Risk Index-Ⅱ performed best (area under the curve 0.77, sensitivity 75.3%, specificity 66.3%).

Conclusion

Except for HDL-C, other studied lipid variables were positively associated with CVD risk, albeit remnant cholesterol showed a weaker association. cardiovascular risk index -Ⅱ provided the best discrimination for future CVD events in this rural Uyghur population.

Key words: Dyslipidemia, Lipid parameters, Lipid ratios, Cardiovascular disease, Xinjiang Corps, Rural residents, Cohort study

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