切换至 "中华医学电子期刊资源库"

中华心脏与心律电子杂志 ›› 2022, Vol. 10 ›› Issue (03) : 151 -155. doi: 10.3877/cma.j.issn.2095-6568.2022.03.005

所属专题: 总编推荐

心血管急危重症

钠-葡萄糖协同转运蛋白2抑制剂恩格列净的心力衰竭相关研究进展
吴颖1, 郦明芳1,()   
  1. 1. 210029 南京,南京医科大学第一附属医院(江苏省人民医院)心血管内科
  • 收稿日期:2022-06-15 出版日期:2022-09-25
  • 通信作者: 郦明芳

Research advance of the effect of SGLT2 inhibitor empagliflozin in heart failure

Ying Wu1, Mingfang Li1,()   

  1. 1. Department of Cardiology, The First Affiliated Hospital with Nanjing Medical University (Jiangsu Province Hospital), Nanjing 210029, China
  • Received:2022-06-15 Published:2022-09-25
  • Corresponding author: Mingfang Li
引用本文:

吴颖, 郦明芳. 钠-葡萄糖协同转运蛋白2抑制剂恩格列净的心力衰竭相关研究进展[J]. 中华心脏与心律电子杂志, 2022, 10(03): 151-155.

Ying Wu, Mingfang Li. Research advance of the effect of SGLT2 inhibitor empagliflozin in heart failure[J]. Chinese Journal of Heart and Heart Rhythm(Electronic Edition), 2022, 10(03): 151-155.

糖尿病和心力衰竭作为全球疾病负担,与之相关的治疗研究进展一直备受关注。恩格列净是钠-葡萄糖协同转运蛋白2抑制剂(SGLT2i)中的一种,不仅作为新型降糖药物近年来广受欢迎,且目前已有相关研究表明其对心力衰竭也同样有获益,是目前被证明可降低心血管死亡发生风险的SGLT-2i。恩格列净的有效性及安全性在得到证实的同时,其治疗心力衰竭的机制也成为如今的研究热点。

[1]
The Food and Drug Administration. Guidance for industry: Diabetes Mellitus—evaluating cardiovascular risk in new antidiabetic therapies to treat type 2 diabetes[EB/OL].(2008-12-19)[2022-09-09].

URL    
[2]
GBD 2016 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016[J]. Lancet, 2017, 390(10100): 1211-1259.
[3]
Bozkurt B, Coats AJS, Tsutsui H, et al. Universal definition and classification of heart failure: a report of the Heart Failure Society of America, Heart Failure Association of the European Society of Cardiology, Japanese Heart Failure Society and Writing Committee of the Universal Definition of Heart Failure: Endorsed by the Canadian Heart Failure Society, Heart Failure Association of India, Cardiac Society of Australia and New Zealand, and Chinese Heart Failure Association[J]. Eur J Heart Fail, 2021, 23(3): 352-380.
[4]
中华医学会心血管病学分会代谢性心血管疾病学组, 中华心血管病杂志编辑委员会. 心血管病合并糖代谢异常患者心血管风险综合管理中国专家共识[J]. 中华心血管病杂志, 2021, 49(7): 656-672.
[5]
Häring H-U, Merker L, Seewaldt-Becker E, et al. Empagliflozin as add-on to metformin in patients with type 2 diabetes: a 24-week, randomized, double-blind, placebo-controlled trial [J]. Diabetes Care, 2014, 37(6): 1650-1659.
[6]
Kohler S, Zeller C, Iliev H, et al. Safety and tolerability of Empagliflozin in patients with type 2 diabetes: pooled analysis of phase I-III clinical trials[J]. Adv Ther, 2017, 34(7): 1707-1726.
[7]
Einarson TR, Acs A, Ludwig C, et al. Prevalence of cardiovascular disease in type 2 diabetes: a systematic literature review of scientific evidence from across the world in 2007-2017[J]. Cardiovasc Diabetol, 2018, 17(1):83.
[8]
Fitchett D, Inzucchi SE, Cannon CP, et al. Empagliflozin reduced mortality and hospitalization for heart failure across the spectrum of cardiovascular risk in the EMPA-REG OUTCOME trial[J]. Circulation, 2019, 139(11): 1384-1395.
[9]
Mordi NA, Mordi IR, Singh JS, et al. Renal and cardiovascular effects of SGLT2 inhibition in combination with loop diuretics in patients with type 2 diabetes and chronic heart failure: the RECEDE-CHF trial[J]. Circulation, 2020, 142(18):1713-1724.
[10]
Packer M, Butler J, Filippatos GS, et al. Evaluation of the effect of sodium-glucose co-transporter 2 inhibition with empagliflozin on morbidity and mortality of patients with chronic heart failure and a reduced ejection fraction: rationale for and design of the EMPEROR-Reduced trial[J]. Eur J Heart Fail, 2019, 21(10): 1270-1278.
[11]
Packer M, Anker SD, Butler J, et al. Cardiovascular and renal outcomes with empagliflozin in heart failure[J]. N Engl J Med, 2020, 383(15): 1413-1424.
[12]
Zannad F, Ferreira JP, Pocock SJ, et al. Cardiac and kidney benefits of empagliflozin in heart failure across the spectrum of kidney function: insights from EMPEROR-Reduced[J]. Circulation, 2021, 143(4): 310-321.
[13]
Butler J, Anker SD, Filippatos G, et al. Empagliflozin and health-related quality of life outcomes in patients with heart failure with reduced ejection fraction: the EMPEROR-Reduced trial[J]. Eur Heart J, 2021, 42(13): 1203-1212.
[14]
Packer M, Anker SD, Butler J, et al. Influence of neprilysin inhibition on the efficacy and safety of empagliflozin in patients with chronic heart failure and a reduced ejection fraction: the EMPEROR-Reduced trial[J]. Eur Heart J, 2021, 42(6): 671-680.
[15]
Santos-Gallego CG, Vargas-Delgado AP, Requena-Ibanez JA, et al. Randomized trial of empagliflozin in nondiabetic patients with heart failure and reduced ejection fraction[J]. J Am Coll Cardiol, 2021, 77(3): 243-255.
[16]
Lee M, Brooksbank K, Wetherall K, et al. Effect of empagliflozin on left ventricular volumes in patients with type 2 diabetes, or prediabetes, and heart failure with reduced ejection fraction (SUGAR-DM-HF)[J]. Circulation, 2021, 143(6):516-525.
[17]
Anker SD, Butler J, Filippatos G, et al. Empagliflozin in heart failure with a preserved ejection fraction[J]. N Engl J Med, 2021, 385(16):1451-1461.
[18]
Butler J, Filippatos G, Jamal Siddiqi T, et al. Empagliflozin, health status, and quality of life in patients with heart failure and preserved ejection fraction: the EMPEROR-Preserved trial[J]. Circulation, 2022, 145(3): 184-193.
[19]
Ferreira JP, Butler J, Zannad F, et al. Mineralocorticoid receptor antagonists and empagliflozin in patients with heart failure and preserved ejection fraction[J]. J Am Coll Cardiol, 2022, 79(12): 1129-1137.
[20]
Voors AA, Angermann CE, Teerlink JR, et al. The SGLT2 inhibitor empagliflozin in patients hospitalized for acute heart failure: a multinational randomized trial[J]. Nat Med, 2022, 28(3): 568-574.
[21]
Kosiborod MN, Angermann CE, Collins SP, et al. Effects of empagliflozin on symptoms, physical limitations, and quality of life in patients hospitalized for acute heart failure: results from the EMPULSE trial[J]. Circulation, 2022, 146(4):279-288.
[22]
Patorno E, Pawar A, Wexler DJ, et al. Effectiveness and safety of empagliflozin in routine care patients: Results from the EMPagliflozin compaRative effectIveness and SafEty (EMPRISE) study[J]. Diabetes Obes Metab, 2022, 24(3):442-454.
[23]
Sheu WH, Seino Y, Tan EC, et al. Healthcare resource utilization in patients treated with empagliflozin in East Asia[J]. J Diabetes Investig, 2022, 13(5):810-821.
[24]
Filion KB, Lix LM, Yu OH, et al. Sodium glucose cotransporter 2 inhibitors and risk of major adverse cardiovascular events: multi-database retrospective cohort study[J]. BMJ, 2020, 370:m3342.
[25]
Sha S, Polidori D, Heise T, et al. Effect of the sodium glucose co-transporter 2 inhibitor canagliflozin on plasma volume in patients with type 2 diabetes mellitus[J]. Diabetes Obes Metab, 2014, 16(11):1087-1095.
[26]
Pfeifer M, Townsend RR, Davies MJ, et al. Effects of canagliflozin, a sodium glucose co-transporter 2 inhibitor, on blood pressure and markers of arterial stiffness in patients with type 2 diabetes mellitus: a post hoc analysis[J]. Cardiovasc Diabetol, 2017, 16(1):29.
[27]
Nakayama H, Ohtsuka Y, Kawahara M, et al. Changes in body composition during SGLT2 inhibitor treatment and their relevance to the improvement of insulin sensitivity[J]. Diabetes Res Clin Pract, 2016, 120: s50-s51.
[28]
Ridderstråle M, Rosenstock J, Andersen KR, et al. Empagliflozin compared with glimepiride in metformin-treated patients with type 2 diabetes: 208-week data from a masked randomized controlled trial[J]. Diabetes Obes Metab, 2018, 20(12):2768-2777.
[29]
Iemitsu K, Iizuka T, Takihata M, et al. Factors influencing changes in hemoglobin A1c and body weight during treatment of type 2 diabetes with ipragliflozin: interim analysis of the ASSIGN-K study[J]. J Clin Med Res, 2016, 8(5): 373-378.
[30]
Verma S, Rawat S, Ho KL, et al. Empagliflozin increases cardiac energy production in diabetes: novel translational Insights into the heart failure benefits of SGLT2 inhibitors[J]. JACC Basic Transl Sci, 2018, 3(5): 575-587.
[31]
Santos-Gallego CG, Requena-Ibanez JA, San Antonio R, et al. Empagliflozin ameliorates adverse left ventricular remodeling in nondiabetic heart failure by enhancing myocardial energetics[J]. J Am Coll Cardiol, 2019, 73(15):1931-1944.
[32]
Lee TI, Chen YC, Lin YK, et al. Empagliflozin Attenuates myocardial sodium and calcium dysregulation and reverses cardiac remodeling in streptozotocin-Induced diabetic Rats[J]. Int J Mol Sci, 2019, 20(7): 1680-1698.
[33]
Zhou H, Wang S, Zhu P, et al. Empagliflozin rescues diabetic myocardial microvascular injury via AMPK-mediated inhibition of mitochondrial fission[J]. Redox Biol, 2018, 15: 335-346.
[34]
Wu P, Wen W, Li J, et al. Systematic review and meta-Analysis of randomized controlled trials on the effect of SGLT2 inhibitor on blood leptin and adiponectin level in patients with type 2 diabetes[J]. Horm Metab Res, 2019, 51(8): 487-494.
[35]
Mcdonagh TA, Metra M, Adamo M, et al. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure [J]. Eur Heart J, 2021, 42(36): 3599-3726.
[1] 李颖, 潘绍卿, 丁明岩, 孙丹丹, 曲海波, 侯培培, 朱芳. 实时三维超声心动图对高度房室传导阻滞伴射血分数保留的心力衰竭患者左束支区域起搏后左心室功能及同步性的评价[J]. 中华医学超声杂志(电子版), 2023, 20(04): 430-436.
[2] 刘一凡, 高迪, 董佳, 朱凯媛, 潘新, 张风雷, 徐大春, 鄢春喜. 可溶性生长刺激表达基因2蛋白对急性心力衰竭住院患者的预后评估价值[J]. 中华危重症医学杂志(电子版), 2023, 16(01): 13-19.
[3] 庞慧, 纵振坤, 郭鹏, 魏鹏, 郝林. CHA2DS2-VASc评分在心力衰竭患者血栓栓塞风险预测中的应用[J]. 中华危重症医学杂志(电子版), 2022, 15(04): 285-290.
[4] 郑珊珊, 郑哲, 黄洁, 廖中凯, 宋云虎, 房晓楠, 刘盛. 主动脉内球囊反搏作为心脏移植桥接治疗对晚期心力衰竭合并肺动脉高压患者的疗效[J]. 中华移植杂志(电子版), 2022, 16(05): 277-284.
[5] 孙雪峰. 肾素-血管紧张素-醛固酮系统抑制剂治疗伴有心力衰竭的慢性肾脏病[J]. 中华肾病研究电子杂志, 2022, 11(06): 301-306.
[6] 王震, 杨晓月, 苏康康, 王朝阳, 李少杰, 陈淑霞, 谷剑. β受体阻滞剂对心力衰竭合并房颤患者预后影响的研究进展[J]. 中华临床医师杂志(电子版), 2023, 17(04): 479-482.
[7] 王志明, 黄岳青, 马庆华, 陈卫海, 孙勤, 殷人麟, 吴雁鸣, 叶福龙, 尤华, 黄敏. “专科-全科”一体化联合管理在老年非瓣膜性房颤合并心衰患者中的应用:一项倾向性评分匹配研究[J]. 中华临床医师杂志(电子版), 2022, 16(12): 1188-1193.
[8] 李明雪, 李子墨, 田建立. 血压与心力衰竭的关系:研究现状与挑战[J]. 中华临床医师杂志(电子版), 2022, 16(08): 805-809.
[9] 唐红燕, 丹海俊, 高志红, 张作阳, 翟书梅, 吴少玉, 张玉. 心脏彩色多普勒超声在冠心病慢性心力衰竭患者临床诊断中的应用[J]. 中华临床医师杂志(电子版), 2022, 16(07): 676-679.
[10] 宗蔚蔚, 徐冬梅, 张新月, 耿洁. 医护一体化管理模式对沙库巴曲缬沙坦治疗老年心力衰竭患者用药依从性及并发症的影响[J]. 中华临床医师杂志(电子版), 2022, 16(06): 588-592.
[11] 周燕媚, 孙雯, 林琳, 陈娟娟, 杜培丽, 张慧丽, 陈兢思, 杜丽丽, 陈敦金. 子痫前期并发心力衰竭的诊治和评估[J]. 中华产科急救电子杂志, 2022, 11(04): 228-233.
[12] 杨旭希, 郑吉洋, 陈秀梅, 陈淑玲, 杨峻青, 苏芝琪, 左咏臻, 广东省医师协会心力衰竭专业医师分会, 广东省护士协会介入护士分会. 慢性心力衰竭患者容量管理护理专家共识[J]. 中华介入放射学电子杂志, 2023, 11(03): 201-207.
[13] 孔倩文, 刘姗, 曾彩虹, 曾庆春. 有氧运动和抗阻运动对心力衰竭患者心率变异性影响的观察性研究[J]. 中华心脏与心律电子杂志, 2023, 11(03): 160-164.
[14] 张诚霖, 李学美, 巫惠心, 李晓燕. 心力衰竭患者容量管理护理质量评价指标体系的构建[J]. 中华心脏与心律电子杂志, 2023, 11(03): 173-178.
[15] 黎俊聪, 黄莹, 杨婵娟, 屠燕. 钠-葡萄糖共转运体2抑制剂治疗心力衰竭的研究进展[J]. 中华心脏与心律电子杂志, 2023, 11(01): 45-49.
阅读次数
全文


摘要