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中华心脏与心律电子杂志 ›› 2026, Vol. 14 ›› Issue (01) : 11 -18. doi: 10.3877/cma.j.issn.2095-6568.2026.01.002

脉冲电场消融

心脏脉冲电场消融的过去、现在与未来
赵晓溪, 王如兴()   
  1. 214023 无锡,南京医科大学附属无锡人民医院心内科
  • 收稿日期:2025-04-20 出版日期:2026-03-25
  • 通信作者: 王如兴
  • 基金资助:
    国家自然科学基金(82370342); 江苏省自然科学基金(BK20231145)

The past, present and future of cardiac pulsed field ablation

Xiaoxi Zhao, Ruxing Wang()   

  1. Department of Cardiology, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi 214023, China
  • Received:2025-04-20 Published:2026-03-25
  • Corresponding author: Ruxing Wang
引用本文:

赵晓溪, 王如兴. 心脏脉冲电场消融的过去、现在与未来[J/OL]. 中华心脏与心律电子杂志, 2026, 14(01): 11-18.

Xiaoxi Zhao, Ruxing Wang. The past, present and future of cardiac pulsed field ablation[J/OL]. Chinese Journal of Heart and Heart Rhythm(Electronic Edition), 2026, 14(01): 11-18.

心房颤动作为全球最常见的持续性心律失常,其导管消融治疗正经历从传统热能技术如导管射频消融及冷冻消融向非热能技术即脉冲电场消融的革命性转变。脉冲电场消融基于不可逆电穿孔原理,通过高电压短脉冲电场选择性破坏心肌细胞膜结构,实现组织特异性消融,同时规避热损伤相关并发症。

As the most common sustained cardiac arrhythmia worldwide, atrial fibrillation is undergoing a transformative shift in catheter ablation therapy—from conventional thermal techniques, such as radiofrequency ablation and cryoablation, toward non-thermal technology, namely pulsed field ablation. Based on the principle of irreversible electroporation, pulsed field ablation employs high-voltage, short-duration electric fields to selectively disrupt myocardial cell membrane structures, achieving tissue-specific ablation while avoiding thermal injury-related complications.

图1 脉冲电场消融、射频消融和冷冻球囊消融工作原理图17
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