切换至 "中华医学电子期刊资源库"

中华心脏与心律电子杂志 ›› 2026, Vol. 14 ›› Issue (01) : 19 -23. doi: 10.3877/cma.j.issn.2095-6568.2026.01.003

脉冲电场消融

脉冲电场消融治疗心房颤动的研究展望
杨钰粒, 王群山()   
  1. 200092 上海,上海交通大学医学院附属新华医院心血管内科
  • 收稿日期:2025-05-07 出版日期:2026-03-25
  • 通信作者: 王群山
  • 基金资助:
    国家自然科学基金(82370316,82400382); 上海市科委重点(24YL_1900500); 上海申康医院发展中心市级医院新兴前沿联合攻关项目(SHDC12025136)

Advances in pulsed field ablation for the treatment of atrial fibrillation

Yuli Yang, Qunshan Wang()   

  1. Department of Cardiology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai 200092, China
  • Received:2025-05-07 Published:2026-03-25
  • Corresponding author: Qunshan Wang
引用本文:

杨钰粒, 王群山. 脉冲电场消融治疗心房颤动的研究展望[J/OL]. 中华心脏与心律电子杂志, 2026, 14(01): 19-23.

Yuli Yang, Qunshan Wang. Advances in pulsed field ablation for the treatment of atrial fibrillation[J/OL]. Chinese Journal of Heart and Heart Rhythm(Electronic Edition), 2026, 14(01): 19-23.

心房颤动(房颤)是临床常见心律失常,严重影响患者生活质量与长期预后。脉冲场消融(PFA)作为一种新兴能量消融技术,为房颤治疗提供了全新方向。本文从PFA的作用原理、临床疗效、安全性特征及与传统消融技术的对比入手,综述其优势与局限性,深入探讨其在房颤治疗中的研究进展,旨在为临床实践提供理论支撑,同时为后续相关研究指明方向。

Atrial fibrillation (AF) is a prevalent clinical cardiac arrhythmia that exerts a profound adverse impact on patients' quality of life and long-term prognosis. Pulsed field ablation (PFA), as an emerging energy-based ablation technology, has brought a new direction for AF treatment. By elaborating on its mechanism of action, clinical efficacy, safety profile, and comparative analysis with conventional ablation techniques, this review summarizes the advantages and limitations of PFA. Furthermore, it explores the latest research advances of PFA in AF treatment, aiming to provide a theoretical basis for clinical practice, and shed light on the direction of future research.

[1]
Haïssaguerre M, Sanders P, Hocini M, et al. Changes in atrial fibrillation cycle length and inducibility during catheter ablation and their relation to outcome[J]. Circulation, 2004, 109(24):3007-3013.
[2]
唐闽. 脉冲电场消融治疗心房颤动[J/OL]. 中华心脏与心律电子杂志, 2022, 10(1):27 -31.
[3]
蒋子涵, 于丰源, 张宏达, 等. 2023年美国心律学年会心律失常领域最新临床研究进展[J/OL]. 中华心脏与心律电子杂志, 2023, 11(2):125-128.
[4]
Zou F, Di Biase L. Pulsed field ablation[J]. Card Electrophysiol Clin, 2025, 17(2):xv.
[5]
Reddy VY, Neuzil P, Koruth JS, et al. Pulsed field ablation for pulmonary vein isolation in atrial fibrillation[J]. J Am Coll Cardiol, 2019, 74(3):315-326.
[6]
Reddy VY, Dukkipati SR, Neuzil P, et al. Pulsed field ablation of paroxysmal atrial fibrillation: 1-year outcomes of IMPULSE, PEFCAT, and PEFCAT II[J]. JACC Clin Electrophysiol, 2021, 7(5):614-627.
[7]
Reddy Vivek Y, Petr P, Josef K, et al. One-year outcomes of a conformable single-shot pulsed-field ablation catheter for the treatment of paroxysmal atrial fibrillation[J]. Heart Rhythm, 2025, 22(10):2551-2561.
[8]
Parameswaran R, Al-Kaisey AM, Kalman JM. Catheter ablation for atrial fibrillation: current indications and evolving technologies[J]. Nat Rev Cardiol, 2021, 18(3):210-225.
[9]
Scherr D, Turagam MK, Maury P, et al. Repeat procedures after pulsed field ablation for atrial fibrillation: MANIFEST-REDO study[J]. Europace, 2025, 27(8):euaf012.
[10]
Schmidt B, Bordignon S, Neven K, et al. EUropean real-world outcomes with Pulsed field ablatiOn in patients with symptomatic atRIAl fibrillation: lessons from the multi-centre EU-PORIA registry[J]. Europace, 2023, 25(7):euad185.
[11]
Reddy VY, Anic A, Koruth J, et al. Pulsed field ablation in patients with persistent atrial fibrillation[J]. J Am Coll Cardiol, 2020, 76(9):1068-1080.
[12]
Reddy VY, Gerstenfeld EP, Schmidt B, et al. Pulsed field ablation of persistent atrial fibrillation with continuous electrocardiographic monitoring follow-up: ADVANTAGE AF Phase 2[J]. Circulation, 2025, 152(1):27-40.
[13]
Ekanem E, Neuzil P, Reichlin T, et al. Safety of pulsed field ablation in more than 17,000 patients with atrial fibrillation in the MANIFEST-17K study[J]. Nat Med, 2024, 30(7):2020-2029.
[14]
Benali K, Khairy P, Hammache N, et al. Procedure-related complications of catheter ablation for atrial fibrillation[J]. J Am Coll Cardiol, 2023, 81(21):2089-2099.
[15]
Kuroki K, Whang W, Eggert C, et al. Ostial dimensional changes after pulmonary vein isolation: pulsed field ablation vs radiofrequency ablation[J]. Heart Rhythm, 2020, 17(9):1528-1535.
[16]
Verma A, Haines DE, Boersma LV, et al. Pulsed field ablation for the treatment of atrial fibrillation: PULSED AF pivotal trial[J]. Circulation, 2023, 147(19):1422-1432.
[17]
Iacopino S, Filannino P, Artale P, et al. Investigating deep sedation with intravenous ketamine in spontaneous respiration during pulsed-field ablation[J]. J Cardiothorac Vasc Anesth, 2024, 38(1):148-154.
[1] 胡昕, 马丹珂, 杨曼曼, 王烁晶, 崔存英, 刘琳, 王成增. 四维自动左心房定量技术评价射血分数保留型心力衰竭合并阵发性心房颤动患者的左心房结构和功能[J/OL]. 中华医学超声杂志(电子版), 2025, 22(12): 1097-1105.
[2] 华义, 王华, 杨旭. 习惯性髌骨脱位的治疗现状与进展[J/OL]. 中华损伤与修复杂志(电子版), 2025, 20(04): 347-351.
[3] 尹晓南, 杨弘鑫, 沈朝勇, 尹源, 张波. 胃肠间质瘤四线瑞派替尼的耐药机制及治疗进展[J/OL]. 中华普通外科学文献(电子版), 2025, 19(06): 414-420.
[4] 杨培容, 潘刚, 周春霞. 胰腺癌术后胰瘘的危险因素及治疗进展[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(02): 228-230.
[5] 阿里木江·马木提, 吐尔洪江·吐逊. 肝泡型棘球蚴病外科治疗进展[J/OL]. 中华肝脏外科手术学电子杂志, 2025, 14(03): 475-480.
[6] 周涛, 程梓荷, 郑宏芳, 刘佳奇, 许雪琴, 王胜昱. 脓毒症合并新发心房颤动抗凝治疗策略的研究进展[J/OL]. 中华重症医学电子杂志, 2025, 11(04): 402-406.
[7] 赵晓溪, 王如兴. 心脏脉冲电场消融的过去、现在与未来[J/OL]. 中华心脏与心律电子杂志, 2026, 14(01): 11-18.
[8] 王皓铖, 王际凯, 刘梓瑞, 孙云娟, 周靖, 刘洋, 曹明强, 邹操. 三维标测系统结合心腔内超声指导心房颤动零射线射频导管消融的可行性[J/OL]. 中华心脏与心律电子杂志, 2025, 13(04): 214-220.
[9] 翟正芹, 周益锋. 脉冲电场消融治疗室性心律失常进展[J/OL]. 中华心脏与心律电子杂志, 2025, 13(04): 229-234.
[10] 王哲宁, 李岳春. 导管消融治疗持续性心房颤动的现状与挑战[J/OL]. 中华心脏与心律电子杂志, 2025, 13(04): 235-241.
[11] 沙剑梅, 丁祥伟, 朱莉. 心房颤动合并心力衰竭患者导管消融的研究进展[J/OL]. 中华心脏与心律电子杂志, 2025, 13(03): 164-172.
[12] 刘铮, 张建军, 刘兴鹏, 刘丽凤, 张婉菁, 左琨, 刘小青. 右心房插入点消融阻断心房间连接治疗顽固性右肺静脉电传导恢复一例[J/OL]. 中华心脏与心律电子杂志, 2025, 13(02): 120-123.
[13] 中国医师协会心血管内科医师分会结构性心脏病学组;苏州工业园区东方华夏心血管健康研究院. 中国经导管左心耳封堵术临床路径专家共识(2025版)[J/OL]. 中华心脏与心律电子杂志, 2025, 13(01): 1-28.
[14] 肖瑶, 白玉瀛, 陶文丹, 吴波. 心房颤动治疗对认知功能影响的系统评价再评价[J/OL]. 中华脑血管病杂志(电子版), 2025, 19(03): 234-243.
[15] 付志勇, 马欣, 董静, 杜祥颖, 尹春琳. 压力感受器分布动脉的粥样硬化总负荷对卒中后新监测到的心房颤动的影响[J/OL]. 中华脑血管病杂志(电子版), 2025, 19(03): 175-183.
阅读次数
全文


摘要


AI


AI小编
你好!我是《中华医学电子期刊资源库》AI小编,有什么可以帮您的吗?