Comparison of Ramosetron′s and Ondansetron′s Preventive Anti-emetic Effects: A Systematic Review and Meta-analysis

doi:10.3877/cma.j.issn.2095-6568.2017.03.005

Abstract

Abstract:

Objective

The aim of this study was to systematicallyand objectively compare the anti-emetic effects of ramosetron and ondansetron on postoperative nausea and vomiting.

Methods

A systematic literature search of MEDLINE, Web of Science, Cochrane Library and the Google scholar were performed to recruit studies compared ramosetron and ondansetron in the treatment of postoperative nausea and vomiting.A Meta-analysis(R-3.1.3) was conducted to estimate the effect of different interventions.

Results

A total of 12 randomized controlled trails met the inclusion criteria.The study demonstrates that ramosetron is more effective than ondansetron for the prevention of postoperative nausea and vomiting.

Conclusions

Use of ramosetron is a more effective mean for reducing postoperative nausea and vomiting than ondansetron.

Key words: Ramosetron, Ondansetron, Postoperative nausea and vomiting, Meta-analysis

Zhonghua Zhang, Guangtao Zhang, YunQian Li. Comparison of Ramosetron′s and Ondansetron′s Preventive Anti-emetic Effects: A Systematic Review and Meta-analysis[J]. Chinese Journal of Heart and Heart Rhythm(Electronic Edition), 2017, 05(03): 144-148.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhxzyxldzzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2095-6568.2017.03.005

https://zhxzyxldzzz.cma-cmc.com.cn/EN/Y2017/V05/I03/144

Figures/Tables 7

References 23

[1]	Islam S, Jain PN. Post-operative nausea and vomiting (PONV)：a review article[J]. Indian Journal of Anaesth 2004；48：253-8.
[2]	Haynes G R, Bailey M K. Postoperative nausea and vomiting: review and clinical approaches[J]. Southern medical journal, 1996, 89(10): 940-949.
[3]	vanWijk MG, Smalhout B. A postoperative analysis of the patient′s viewof anaesthesia in a Netherlands′ teaching hospital.[J]. Anaesthesia, 1990，45(8)：679-682.
[4]	Gan TJ. Postoperative nausea and vomiting—Can it be eliminated？[J]．Jama, 2002, 287(10): 1233-1236.
[5]	Korttila K. The study of postoperative nausea and vomiting[J]. British journal of anaesthesia, 1992, 69(7): 20S-23S.
[6]	Apfel CC, Roewer N. Postoperative nausea and vomiting[J]. Der Anaesthesist, 2004, 53(4): 377-89; quiz 390-1.
[7]	McCracken G, Houston P, Lefebvre G. Guideline for the management of postoperative nausea and vomiting[J]. Journal of obstetrics and gynaecology Canada: JOGC＝ Journal d'obstetrique et gynecologie du Canada: JOGC, 2008, 30(7): 600-7, 608-16.
[8]	Tramèr MR. Treatment of postoperative nausea and vomiting: Betterdata, improved control have been achieved during recent years[J]. BMJ：British Medical Journal, 2003, 327(7418): 762.
[9]	Kenny GNC. Risk factors for postoperative nausea and vomiting[J]．Anaesthesia, 1994, 49(1): 6-10.
[10]	Alkaissi A, Gunnarsson H, Johnsson V, et al. Disturbing postoperative symptoms are not reduced by prophylactic antiemetic treatment in patients at high risk of post‐operative nausea and vomiting[J]. Acta anaesthesiologica scandinavica, 2004, 48(6): 761-771.
[11]	Jadad AR, Moore R A, Carroll D, et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary？[J]．Controlled clinical trials, 1996, 17(1): 1-12.
[12]	Kaja S, Giri RS, Tugave DV, et al. A randomized clinical trial comparing the efficacy and safety of ramosetron versus ondansetron in patients undergoing abdominal surgery under general anesthesia[J]. Saudi journal of anaesthesia, 2014, 8(1): 59.
[13]	Ryu JH, Lee JE, Lim YJ, et al. A prospective, randomized，double-blind, and multicenter trial of prophylactic effects of ramosetronon postoperative nausea and vomiting (PONV) after craniotomy：comparison with ondansetron[J]. BMC anesthesiology, 2014, 14(1): 1-8.
[14]	Choi YS, Shim JK, Ahn SH, et al. Efficacy comparison of ramosetron with ondansetron on preventing nausea and vomiting in high-risk patients following spine surgery with a single bolus of dexamethasone as an adjunct[J]. Korean journal of anesthesiology, 2012, 62(6): 543-547.
[15]	Lee JW, Park HJ, Choi J, et al. Comparison of ramosetron′s and ondansetron′s preventive anti-emetic effects in highly susceptible patients undergoing abdominal hysterectomy[J]. Korean journal of anesthesiology, 2011, 61(6): 488-492.
[16]	Choi DK, Chin JH, Lee EH, et al. Prophylactic control of post－operative nausea and vomiting using ondansetron and ramosetron after cardiac surgery[J]. Acta anaesthesiologica Scandinavica, 2010, 54(8)：962-969.
[17]	Ryu J, So YM, Hwang J, et al. Ramosetron versus ondansetron for the prevention of postoperative nausea and vomiting after laparoscopic cholecystectomy[J]. Surgical endoscopy, 2010, 24(4): 812-817.
[18]	Ansari MM, Siddiqui OA, Haleem S, et al. Comparison of ramosetron and ondansetron for control of post-operative nausea and vomiting following laparoscopic cholecystectomy[J]. Indian journal of medical sciences, 2010, 64(6): 272.
[19]	Hahm TS, Ko JS, Choi SJ, et al. Comparison of the prophylactic anti－emetic efficacy of ramosetron and ondansetron in patients at high－risk for postoperative nausea and vomiting after total knee replacement[J]. Anaesthesia, 2010, 65(5): 500-504.
[20]	Kim SI, Kim SC, Baek YH, et al. Comparison of ramosetron with ondansetron for prevention of postoperative nausea and vomiting in patients undergoing gynaecological surgery[J]. British journal of anaesthesia, 2009, 103(4): 549-553.
[21]	Choi YS, Shim JK, Jeon DH, et al. Effect of ramosetron on patient-controlled analgesia related nausea and vomiting after spine surgery in highly susceptible patients: comparison with ondansetron[J]．Spine, 2008, 33(17): E602-E606.
[22]	Kim SH, Hong JY, Kim WO, et al. Palonosetron has superior prophylactic antiemetic efficacy compared with ondansetron or ramosetron in high-risk patients undergoing laparoscopic surgery: a prospective，randomized, double-blinded study[J]. Korean journal of anesthesiology，2013, 64(6): 517-523.
[23]	Swaika S, Pal A, Chatterjee S, et al. Ondansetron, ramosetron, or palonosetron: Which is a better choice of antiemetic to preventpostoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy？[J]. Anesthesia, Essays and Researches, 2011, 5(2): 182.

纳入研究	JADAD评分	干预	人数	患者一般信息		手术类型	手术时间(min)	数据采集的时间(h)
纳入研究	JADAD评分	干预	人数	年龄(Y)	体质量(kg)	手术类型	手术时间(min)	数据采集的时间(h)
Phillips and Hutchinson	B	G	40	35	67	腹腔镜	25	24
?	?	P	40	31	66	?	25	?
Pongprojpaw and Chiamchanya	B	G	40	32	53	腹腔镜	72	0，4，24
?	?	P	40	34	52	?	70	?
Eberhart et al.	A	G	57	57	N	腹腔镜	34	0，3，6，24
?	?	P	59	59	N	?	34	?
Nanthakomon et al.	A	G	60	41	58	开腹	127	0，2，6，12，24
?	?	P	60	41	54	?	128	?
Kalava et al.	A	G	116	33	N	剖宫产	45	2，2.5，24
?	?	P	123	33	N	?	45	?
Janngam et al.	A	G	54	37	61	四肢手术	100	0，6，24
?	?	P	54	35	61	?	?	?
Bone et al.	B	G	20	40	63	混合	58	0，2，12，24
?	?	P	20	46	61	?	52	?
Visalyaputra et al.	B	G	27	32	51	腹腔镜	20	24
?	?	P	28	33	51	?	41	?

纳入研究	JADAD评分	干预	人数	患者一般信息		手术类型	手术时间(min)	数据采集的时间(h)
纳入研究	JADAD评分	干预	人数	年龄(Y)	体质量(kg)	手术类型	手术时间(min)	数据采集的时间(h)
Phillips and Hutchinson	B	G	40	35	67	腹腔镜	25	24
?	?	P	40	31	66	?	25	?
Pongprojpaw and Chiamchanya	B	G	40	32	53	腹腔镜	72	0，4，24
?	?	P	40	34	52	?	70	?
Eberhart et al.	A	G	57	57	N	腹腔镜	34	0，3，6，24
?	?	P	59	59	N	?	34	?
Nanthakomon et al.	A	G	60	41	58	开腹	127	0，2，6，12，24
?	?	P	60	41	54	?	128	?
Kalava et al.	A	G	116	33	N	剖宫产	45	2，2.5，24
?	?	P	123	33	N	?	45	?
Janngam et al.	A	G	54	37	61	四肢手术	100	0，6，24
?	?	P	54	35	61	?	?	?
Bone et al.	B	G	20	40	63	混合	58	0，2，12，24
?	?	P	20	46	61	?	52	?
Visalyaputra et al.	B	G	27	32	51	腹腔镜	20	24
?	?	P	28	33	51	?	41	?

纳入研究	术后呕吐(POV)		术后恶心呕吐(PONV)
Phillips and Hutchinson	4/40	9/40	19/40	25/40
Pongprojpaw and Chiamchanya	7/40	12/40	12/40	23/40
Eberhart et al.	23/57	16/59	30/57	29/59
Nanthakomon et al.	17/60	28/60	29/60	40/60
Kalava et al.	N	N	60/116	75/123
Janngam et al.	15/54	24/54	21/54	33/54
Bone et al.	9/20	14/20	N	N
Visalyaputra et al.	7/27	10/28	N	N

纳入研究	术后呕吐(POV)		术后恶心呕吐(PONV)
Phillips and Hutchinson	4/40	9/40	19/40	25/40
Pongprojpaw and Chiamchanya	7/40	12/40	12/40	23/40
Eberhart et al.	23/57	16/59	30/57	29/59
Nanthakomon et al.	17/60	28/60	29/60	40/60
Kalava et al.	N	N	60/116	75/123
Janngam et al.	15/54	24/54	21/54	33/54
Bone et al.	9/20	14/20	N	N
Visalyaputra et al.	7/27	10/28	N	N

项目	0～2 h	6～24 h	24～48 h
Begg检验P值	0.3272	0.8806	0.2971
Egger检验P值	0.1943	0.3498	0.2391

Please choose a citation manager

Content to export