The levels of serum complement C3, C4 and HDL-C in patients with coronary heart disease

doi:10.3877/cma.j.issn.2095-6568.2018.02.002

Abstract

Abstract:

Objective

To analyze the levels of serum complement C3, C4 and HDL-C in patients with coronary atherosclerotic heart disease (CHD).

Methods

A total of 137 patients with CHD admitted to Xi'an No.5 Hospital from May of 2016 to October of 2017 were divided into acute coronary syndrome group (ACS group, 80 cases) and stable coronary heart disease group (SCHD group, 57 cases). Sixty healthy persons in the same period were selected as the control group. The levels of complement C3, C4 and HDL-C were compared among the 3 groups, and the correlation between complement C3, C4 levels and HDL-C level was analyzed.

Results

The level of complement C3 in ACS group and SCHD group was higher than that in control group (P<0.05); the level of complement C3 in ACS group was higher than that in SCHD group (P<0.05); the level of complement C4 in ACS group was higher than that in control group (P<0.05); the level of complement C4 in SCHD group was lower than that in control group (P<0.05); the level of HDL-C in control group was higher than that in ACS group and SCHD group (P<0.05). Serum complement C3 and C4 levels in ACS group and SCHD group were not correlated with HDL-C levels (P>0.05), while serum complement C3 levels in control group were negatively correlated with HDL-C levels (P<0.05).

Conclusion

The levels of serum complement C3 and C4 increased and HDL-C decreased in CHD patients. Inflammation affected the correlation between serum complement and HDL-C levels.

Key words: Coronary heart disease, Complement, High density lipoprotein cholesterol

Cheng Li, Dan Liu. The levels of serum complement C3, C4 and HDL-C in patients with coronary heart disease[J]. Chinese Journal of Heart and Heart Rhythm(Electronic Edition), 2018, 06(02): 68-70.

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组别	例数	补体C3(mg/L)	补体C4(mg/L)	HDL－C(mmol/L)
对照组	60	804.19±77.92	254.26±31.49	1.53±0.24
ACS组	80	962.63±88.79^a	282.43±44.91^a	1.20±0.28^a
SCHD组	57	918.63±94.26^ab	224.14±39.57^ab	1.25±0.31^a

组别	例数	补体C3(mg/L)	补体C4(mg/L)	HDL－C(mmol/L)
对照组	60	804.19±77.92	254.26±31.49	1.53±0.24
ACS组	80	962.63±88.79^a	282.43±44.91^a	1.20±0.28^a
SCHD组	57	918.63±94.26^ab	224.14±39.57^ab	1.25±0.31^a

组别		r值	P值
ACS组		?	?
?	C3与HDL－C	－0.933	0.491
?	C4与HDL－C	－0.155	0.163
SCHD组		?	?
?	C3与HDL－C	－0.119	0.377
?	C4与HDL－C	－0.191	0.155
对照组		?	?
?	C3与HDL－C	－0.260	0.045
?	C4与HDL－C	－0.200	0.125

组别		r值	P值
ACS组		?	?
?	C3与HDL－C	－0.933	0.491
?	C4与HDL－C	－0.155	0.163
SCHD组		?	?
?	C3与HDL－C	－0.119	0.377
?	C4与HDL－C	－0.191	0.155
对照组		?	?
?	C3与HDL－C	－0.260	0.045
?	C4与HDL－C	－0.200	0.125

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