Premature ventricular contraction (PVC) is a commonly encountered clinical arrhythmia, for which radiofrequency catheter ablation is a first-line treatment. The success rate of ablation therapy is highly dependent on the site of PVC origin. Papillary muscles, characterized by their columnar anatomical structure within the ventricles, exhibit inherent anatomical variations that often lead to challenges in achieving stable catheter contact, thereby increasing the complexity of radiofrequency ablation procedures. Pulsed-field ablation (PFA), as an emerging ablation modality, not only offers favorable tissue selectivity and safety profiles but also demonstrates ablation depth that is not solely dependent on contact force. Currently, reports on PFA for the treatment of PVCs remain scarce. This article presents a case of PVCs originating from the anterior papillary muscle of the left ventricle that were successfully treated with pulse field ablation.