To explore the effect of extracorporeal counterpulsation in the treatment of coronary atherosclerosis.

A retrospective case-control study was conducted. Clinical data of 220 patients with coronary atherosclerosis admitted to the Second Affiliated Hospital of Zhengzhou University from December 2015 to December 2016 were collected. According to the treatment plan, the patients were divided into observation group and control group, 110 cases in each group. The control group was treated with standard coronary artery disease drugs. The observation group was treated with external counterpulsation on the basis of the control group. After three consecutive courses of treatment, cardiac output (CO), stroke output (SV), cardiac index (CI), acceleration index (ACI) and other ventricular function indexes were measured. Peripheral venous blood was taken to measure prostacyclin (PGI₂) and thromboxane A₂ (TXA) in the two groups. The expression levels of TXA₂, nitric oxide (NO), endothelin-1 (ET-1). After 3 months of follow-up, the changes of angina pectoris, nitroglycerin (NTG) dosage and exercise tolerance in the two groups were counted. The observation indexes of the two groups were compared, and the application effect of external counterpulsation technology was discussed.

After treatment, CO, SV, CI and ACI in the observation group were higher than those in the control group (all P<0.05). After treatment, the levels of PGI₂ and NO in the observation group were higher than those in the control group, and the levels of TXA₂ and ET-1 in the observation group were lower than those in the control group (all P<0.05). The improvement rate of angina pectoris, the decrease rate of NTG dosage and the increase rate of exercise tolerance in the observation group were higher than those in the control group (all P<0.05).

External counterpulsation can effectively improve the function of vascular endothelial cells, optimize the expression of related cytokines, improve ventricular ejection function, improve treatment efficiency and exercise tolerance, and ensure the quality of life in patients with coronary atherosclerosis. It is worthy of clinical application.