To analyze the levels of cardiac markers and echocardiographic features in patients with chronic heart failure (CHF).

A total of 82 CHF patients admitted into the Second People’s Hospital of Taixing City from April 2017 to March 2018 were selected as CHF group, and 24 healthy volunteers were selected as control group. CHF patients were divided into four CHF subgroups according to cardiac function classification: 23 cases of CHF grade 1, 25 cases of CHF grade 2, 21 cases of CHF grade 3 and 13 cases of CHF grade 4. The levels of brain natriuretic peptide (BNP) and growth differentiation factor-15 (GDF-15) in peripheral blood were measured. The interventricular septal end-diastolic thickness (IVSTD), left ventricular posterior wall diastolic thickness (LVPWTD), left ventricular end-diastolic diameter (LVDD) and left atrial end-systolic diameter (LAD) were measured by echocardiography. Left ventricular ejection fraction (EF), cardiac output (CO) and cardiac index (CI) were calculated by Simpson formula. Mitral flow spectra were obtained from apical four-chamber section. The maximum early diastolic velocity (E peak), late diastolic maximum velocity (A peak), E/A, early diastolic rapid filling fraction (RFF), left ventricular mass index (LVMI), relative wall thickness (RWT) were collected and compared between the two groups.

Compared with the control group, the levels of BNP and GDF-15 in peripheral blood of CHF group increased significantly (P<0.05). The levels of BNP and GDF-15 in peripheral blood increased with the decrease of cardiac function (P<0.05). Compared with the control group, IVSTD, LVPWTD, LVDD, LAD, LVMI, RWT, CO and A in CHF group increased significantly (P<0.05). CI, EF, E/A and RFF decreased significantly (P<0.05). IVSTD, LVPWTD, LVDD, LAD, LVMI, RWT, CO and A also increased significantly (P<0.05), CI, EF, E/A and RFF also decreased significantly (P<0.05).

The cardiac markers BNP and GDF-15 of CHF increased significantly, and the indexes of echocardiography were abnormal. The abnormal mainly manifestation was left ventricular failure.