Influence of warfarin anticoagulant therapy on electrocardiogram and blood NT-proBNP level in patients with chronic heart failure

doi:10.3877/cma.j.issn.2095-6568.2018.04.005

Abstract

Abstract:

Objective

To investigate the influence of warfarin anticoagulant therapy on electrocardiogram and blood NT-proBNP level in patients with chronic heart failure.

Methods

A total of 120 patients with chronic heart failure admitted to Jiaozhou People's Hospital from September 2015 to December 2018 were selected. All patients were divided into control group and observation group with 60 cases each by random number table method. The control group received routine anti-heart failure treatment, while the observation group received warfarin treatment on the basis of the control group. The changes of left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEDD) and blood NT-proBNP were compared between the two groups.

Results

After treatment, there was no significant difference in LVEDD between the two groups (P>0.05). LVEF in the observation group was higher than that in the control group (P<0.05). The levels of NT-proBNP in the two groups decreased after treatment, and the observation group had a larger change range, with a significant difference (P<0.05).

Conclusion

Warfarin can reduce the level of NT-proBNP in patients with chronic heart failure and improve cardiac function. It has significant clinical application value.

Key words: Chronic heart failure, Warfarin, Electrocardiogram, N-terminal pro-B-type natriuretic peptide

Yongjiang Liu, Jinming Zhang. Influence of warfarin anticoagulant therapy on electrocardiogram and blood NT-proBNP level in patients with chronic heart failure[J]. Chinese Journal of Heart and Heart Rhythm(Electronic Edition), 2018, 06(04): 209-211.

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References 8

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组别	例数	LVEF(%)		LVEDD(mm)
组别	例数	治疗前	治疗后	治疗前	治疗后
对照组	60	36.58±4.42	40.69±5.03^a	57.96±6.83	56.24±6.09
观察组	60	36.52±4.47	44.81±5.26^ab	57.91±6.88	55.37±6.04

组别	例数	LVEF(%)		LVEDD(mm)
组别	例数	治疗前	治疗后	治疗前	治疗后
对照组	60	36.58±4.42	40.69±5.03^a	57.96±6.83	56.24±6.09
观察组	60	36.52±4.47	44.81±5.26^ab	57.91±6.88	55.37±6.04

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